What analogue of "Pregnil" to use? Comparison of the analogues of "Pregnil"
"Pregnil" is used in the treatment of anovulatoryinfertility in women, miscarriage of the fetus, the threat of self-abortion, as well as for the purpose of controlled hyperstimulation of the ovaries, induction of ovulation and an increase in the level of estrogens. Its use is effective in the scheme of replacement therapy of endogenous lutein hormone to stimulate the maturation of follicles.
Indications for use in men are the delaysexual development, associated with hypofunction of sexual glands, cryptorchidism, impaired spermatogenesis. Consider the most famous analogue of "Pregnil" in this article.
Description of the drug "Pregnil"
"Pregnil" contains chorionic gonadotropin(HG) of the person. This hormone begins to produce chorionic tissue after embryo implantation is completed. HG possesses follicle-stimulating and luteinizing activity, enhances the secretion of estrogens and initiates the process of ovulation. Further supports the functional activity of the yellow body before the production of estrogen and progesterone by the placenta.
The use of exogenous chorionicgonadotropin not only increases the secretion of estrogens and progesterone by the ovaries, but also induces ovulation, contributes to the subsequent luteinization of the burst follicle.
The use of drugs HG is most effective in the scheme with the appointment of human menopausal and follicle-stimulating hormones.
Schemes of therapy
"Pregnil" (analogue of "Pregnil" is available in the same dosage) is available in dosages of 1500 and 5000 MO. Used for intramuscular injection.
In the treatment of anovulatory infertility in womena single administration of 5000-10 000 MOs is recommended after completion of FSH therapy (follicle stimulating hormone) or CHMH (human menopausal gonadotropin).
Before the puncture, for control stimulation of the ovaries, after the end of treatment, 5000 IU is administered.
Support for the luteal phase is carried out by cyclic injections at a dosage of 1000 to 3000 MO every three days - 3 times.
In men, it is used for the hypofunction of sexual glands and for the violation of spermatogenesis in dosages of 1000 to 2000 MO several times a week (the analogue of "Pregnil" can be taken in the same way).
When treating cryptorchidism in children, the drug is used 2 times a week, recommended dosages:
- up to 2 years - 250 MO;
- up to 6 years, designate 500 to 1000 MO;
- After 6 years - 1500 MO.
We examined the scheme of application of the drug. But it is best to consult a doctor before starting therapy and get a prescription from him.
Analogues of "Pregnil"
What are the analogues of Pregnil? In fact, there are a lot of them, there are cheaper drugs, there are expensive ones.
"Gonadotropin chorionic" is inexpensiveanalogue of "Pregnil". Produced in a dosage of 500; 1000; 1500 units. It is used intramuscularly. It is prescribed in a dosage of 1500 ED in a day or 3000 ED 2-3 times a week in the treatment of infertility in women. In the treatment of sexual infantilism, 500 to 1000 units are prescribed several times a week, up to 2 months. Children are assigned 500-1000 MOs up to ten years, then - 1500 UED each month up to a month with repeated courses. That is, the preparation of "Pregnil" has cheap analogues.
"Ovitrel" contains choriogonadotropin alfa. Produced in a dosage of 250 μg (6500 IU). It is applied subcutaneously. Stimulates the formation of the yellow body, the maturation of the follicles and ovulation. 250 mcg are equated to 5000 units of human chorionic gonadotropin. When stimulating the ovaries and obtaining superovulation, 250 μg are used, after a course of therapy with human menopausal or follicle-stimulating hormones. In the treatment of anovulation, 1 dose is prescribed the day before the sexual intercourse.
Another analogue of "Pregnil". Produced in a dosage of 1500 and 5000 MO. It is administered intramuscularly. It is used for dysmenorrhea, hypoplasia of sexual glands, sexual infantilism for the purpose of accelerating sexual development, the threat of spontaneous abortion, for induction of superovulation. For the induction of superovulation is prescribed in a dosage of 5000 to 10 000 MO once. In the treatment of habitual abortions it is recommended to use from the first day of pregnancy to 14 weeks, twice a week for 10,000 MO. Treatment of hypogonadism includes the appointment of 1500 to 6000 IU once a week. Androgen deficiency in men is treated with HCG once every two weeks, for three months.
Is produced in a dosage of 5000 IO / ml, forintramuscular injection. Has high effectiveness in the therapy of amenorrhea and anovulatory cycle. It is used in combination with human menopausal gonadotropin (75 MO) up to 10 days either subcutaneously or intramuscularly to increase estrogen secretion. When a mature follicle appears on the ultrasound for induction of ovulation, from 5000 to 10 000 MO "Choriomon" are injected. The drug is administered 1-2 days after the last injection of CHMG or FSH. The sexual act is recommended daily before ovulation.
Infertility due to insufficiency of the luteal phase of "Chorionum" is used for 5000 MO on the 21st, 23rd and 25th days of the cycle.
"Prophase" is an analogue of "Pregnil 5000". Produced in a dosage of 2000 and 5000 MO. It is used intramuscularly. Therapy of anovulatory infertility is performed by the introduction of 10 000 MO in the middle of the cycle, after treatment with HMG or FSH. For induction of superovulation, 10,000 IU are prescribed per day before ovum collection. When the yellow body is deficient, the introduction of 5000 MO is recommended, on the fifth and ninth days after ovulation. "Prophase" is highly effective in the therapy of habitual miscarriage. It is used for 10 000 IU at the first application, then - 5000 IU twice a week to 14 weeks.
Contraindications to the use of drugs HG:
- Hormone-producing tumors of sexual glands.
- Tumors of the hypothalamus and pituitary gland.
- Tumors of the uterus, incompatible with pregnancy.
- Pipe pregnancy in anamnesis three months prior to therapy.
- Polycystic ovary.
- Lactation period.
Side effects from the use of human chorionic gonadotropin:
- Increased irritability, emotional lability, headaches, anxiety.
- Dyspeptic disorders (nausea, vomiting).
- Hypersensitivity of the nipples.
- Gynecomastia in men.
- Rash, hives.
- Ovarian hyperstimulation syndrome.
- Temporary enlargement of the penis, pathological erection.
- Decreased work of the pituitary gland.
- Decrease in the volume of circulating blood (hypovolemia).
- Accumulation of blood in the abdominal cavity.
- Multiple pregnancy.
- Fluid retention, pronounced, common swelling.
The analogue of "Pregnil 1500" is ineffective whencongenital defects in the development of the uterus, appendages and vagina, adhesions in the fallopian tubes, primary failure of the ovaries, large fibroids in the uterus.
All therapy is strictly under observationspecialist and control changes in the analysis, the use of these drugs at home is unacceptable and can lead to irreparable health consequences.
Treatment of anovulatory infertility should be carried out under ultrasound control of follicular growth and constant evaluation of the cervical index.
Daily monitoring of the level of estradiol concentration is important. With the symptom of unwanted hyperstimulation of the ovaries, therapy with the chorionic gonadotropin immediately stops.
We have considered analogues to the preparation of "Pregnil", instructions for their use are also described.